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I am a woman who had been taking zyprexa for about two years, starting on 2.5mg, then 5 mg for the longest time period and then up to 10 mg for awhile but then went back to 5mg. I have gained an enormous amount of weight taking this drug. I went from a healthy 150 to a very unhealthy 233. I did not even notice that I gained so much weight, my mind did not process this information. I take great strides about my weight as at one time I weighted 232 and lost over 80 pounds. I stayed at 145 to 150 for the longest time and my doctor told me zyprexa is at the cause of my weight gain as I am not eating enough to gain this horrible weight. I weaned down to 2.5 mg of zyprexa and now I am off it and have thrown away my pills. I do okay most of the time and then once in awhile I fall into a major crisis and want to cry, scream and just completely lose it. I am a widow and my husband died of alcoholism at age 51 and I have been depressed because of losing my farm and the lifestyle I had grown to love and accept. Now I live by myself and am terribly depressed but will not take zyprexa anymore because of the weight gain. I guess I am looking for understanding here and maybe someone to tell me I am not alone in all this. I need someone to help me understand why this drug has turned on me and why all of a sudden I am so overweight and unhappy. Please someone if you understand, reach out and tell me I am not the only one in this circumstance. I hate the drug. I will be going for a glucose tolerance test when I see the doctor next week. tommie924